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IMSI

A new break through in treating Male infertility

Setting a new precedent for the rest of the country, Lilavati Hospital IVF Centre Mumbai installed a new microscope machine that allows our embryologists to pick the best quality sperm while carrying out the specialized test-tube baby procedure of ICSI.The IMSI technology was introduced in 2009 . Since then the unit has performed more than 300 plus IMSI cycles till date .We are some of the less than 50 IVF units all over the world , who have massive experience in this technology . We were the first in India . We introduced IMSI initially at the lilavati hospital unit in Mumbai and almost immediately followed it by introducing IMSI in our IVF unit at the Fortis La Femme Hospital in New Delhi.

Recently in April 2011, our scientific Director Dr Hrishikesh pai was invited to the world conference on ART ,Valencia,conducted by the IVI IVF unit . He presented the units pioneering experience in IMSI . He presented a research paper , in which 90 patients undergoing IMSI were compared with 90 patients undergoing the traditional ttechnique of ICSI . All patients had either a severe male factor such as poor sperm count , poor sperm motility , abnormal looking sperms or patients with previous two recurrent IVF failures. The pregnancy rates were far better following IMSI.

Intra-Cytoplasmic Morphologically Selected Sperm Injection (IMSI) helps magnify the image of the sperm 7,200 times, thereby allowing our embryologists to pick the best looking healthier sperms. The machine is an advanced version of the earlier technique of Intracytoplasmic Sperm Injection (ICSI), having the magnification capacity of 16 times higher than ICSI.

In ICSI technique, an egg is held and injected with a husband sperm, with the help of a machine called micromanipulator. If the husband has no sperms, then sperms are obtained by doing a testicular biopsy. The fertilization occurs outside the woman’s body. The baby/embryo is created outside the body of the mother and then placed inside the mother’s womb.

The IMSI method was first developed in 2004 by a team led by Benjamin Bartoov, of Barilan University in Israel, who used IMSI to select those sperms with a shape and size that indicated good genetic quality. The pregnancy rate in patients jumped from 30 % to 66 %.

IMSI helps improve the success rate among men with the worst prognosis and is said to be more beneficial than ICSI in patients with previous two IVF or ICSI failures. It is also useful in couples with unexplained infertility. It has been shown that IMSI resulted in better egg fertilization rates, better quality embryos, better rate of blastocyst formation and therefore better pregnancy rates.Recent metanalysis has shown that the miscarriage rates in patients undergoing IIMSI are lesser than those undergoing ICSI.

Since IMSI has been introduced in our hospital many pregnancies, have been achieved. Recently one patient who had severe male factor infertility and who had failed to fertilize her eggs in previous two attempts of ICSI, they not only achieved fertilization with IMSI but also achieved pregnancy.

Another patient who is high court lawyer in Punjab , and who has had 11 times failure with various IVF units(not ours) , underwent the procedure . His wife conceived at the first embryo transfer attempt and recently delivered a child at Fortis Bloom IVF centre New delhi.

Another Non resident Indian who had seven IV attempts outside , recently delivered a baby following IMSI.

Personally we feel that after ICSI ,which was discovered in 1992, IMSI is a major breakthrough in Fertility Technologies : and will benefit numerous couples to have babies.