Welcome to Bloom IVF
Have you gone through ICSI and IVF cycle failure?
Are you struggling to conceive due to infertility problems?
If you are dealing with severe male infertility, then we have positive news for you.
Through IMSI treatment, we can help you achieve your dream of having a baby.
Dr. Hrishikesh Pai is one of the leading gynecologists in India. In 2007, he initially introduced IMSI treatment in India at the Bloom IVF Centre at Lilavati Hospital, Mumbai. Dr. Hrishikesh Pai has performed numerous IMSI cycles until now.
Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) is an advanced assisted reproductive technology, a boon for severe male factor infertility. IMSI is an advanced version of ICSI having a magnification power of 16 times higher compared to ICSI.
IMSI treatment offers various advantages like improved embryo quality and selection of viable sperms. It also helps to reduce the chances of abortion.
In ICSI, before sperm microinjection, we observe the sperms under the microscope of 500 times magnification. But in IMSI, the sperm is being examined under high power of 6600 times before microinjection. IMSI allows the embryologist to see the spermatozoa’s detailed structure, thereby detecting potential abnormalities in the head, middle-piece, and tail of the sperm. This technique thus enables our embryologists to select healthier sperms.
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After collecting the semen sample, it is first treated with a specific solution to remove any impurities.
An embryologist separates the viable cells utilizing centrifugation on the day of the IMSI procedure.
An embryologist examines the sperms under a microscope for choosing a suitable sperm for injecting in the egg.
IMSI helps to determine the sperm morphology through a high magnification of around 6600X. The embryologist only chooses morphologically normal sperm for injecting in the egg.
Such sperms provide a better pregnancy rate. We can also observe even the minute and multiple vacuoles. Sperms with large vacuoles and abnormal head size are not selected. This way, it helps choose the most viable sperms.
A needle is transvaginally introduced under ultrasound-guidance to aspirate the egg follicles for collecting the eggs. After the egg collection, the eggs are first washed with an enzyme to remove unwanted components. It is then observed under an inverted microscope for choosing healthy eggs.
the selected sperm is then placed in a pipette and then injected into the egg under the microscope. The microinjected eggs are being cultured in a sterile culture petri dish in an incubator overnight.
Further, to observe the signs of fertilization, the microinjected eggs are checked at regular intervals. After the embryo formation, the embryos are inserted into the uterus.
After two weeks, a urinary pregnancy test is done for confirmation of pregnancy to plan further steps.
IMSI treatment in India increases the possibility of embryo fertilization and development, especially in males with failed IVF or ICSI treatment or with a high number of abnormal sperms. The significant feature of IMSI is that it selects the sperm with great precision. It involves the examination of sperms at thousand times increased magnification. Thus, minor morphological sperm abnormalities can be detected, which are usually missed with ICSI. In ICSI, the sperms may look healthy, but they may not have fertilization potential.
We can have a better-selected sperm and better fertilization rate in males with severe oligospermia or asthenozoospermia or teratozoospermia with IMSI. IMSI is better than ICSI for selecting the embryos and thus ensures a better success rate.
In our patients, we have seen that IMSI has improved clinical pregnancy rates. It has also reduced abortion rates in many cases. The viable sperms selected using IMSI can further be used for IVF or ICSI treatment to increase the probability of the treatment’s success.
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Mostly, experts recommend the IMSI treatment in India for men with:
IMSI treatment can be a great choice in conditions like,
The success rate of IMSI in comparison with ICSI at Bloom IVF Clinic:
| IMSI | ICSI | |
|---|---|---|
| Live births | 20%-30% | 25% |
| Risk of miscarriage | 5%-10% | 7% |
| Clinical pregnancy | 35%-44% | 32% |
Through IMSI, we discovered that couples had higher pregnancy and live birth rates and reduced miscarriage rates. MSI also improves the success rate of IVF as it increases embryo implantation rate. Compared to ICSI, IMSI also reduces the aneuploidy rate.
IMSI helps improve the success rate in males with poor prognosis. It is more helpful than ICSI in patients with previous IVF or ICSI failures. IMSI has resulted in improved egg fertilization rates, good quality embryos, improved blastocyst formation rate, and higher pregnancy rates.
Seek an appointment at Bloom IVF Centre and get treated from Dr. Hrishikesh Pai with the excellent male infertility services.
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Due to all these reasons, the specialists suggest IMSI only when low or poor sperm quality or repeated ICSI or IVF failure.
Prenatal sex determination & sex selection is illegal in India and not done here. It is a punishable offence.