How can we enhance the success rate of IVF? It is one of the most often requested topics during a fertility consultation.
The success of IVF is determined by a variety of factors, including the age of the woman, her fertility diagnosis, the number of embryos generated, and the quality of the embryos.
Pre-implantation genetic testing for aneuploidies (PGT-A) (previously known as pre-implantation genetic screening (PGS)) is a test that is performed in conjunction with IVF to improve the chances of a healthy pregnancy.
It is not, however, a guarantee of pregnancy.
PGT-A offers crucial information on the chromosomal health of embryos before the transfer, allowing us to choose the embryo with the best chance of resulting in a healthy pregnancy.
Dr. Hrishikesh Pai is one of the leading gynaecologist in Mumbai for infertility. With his years of expertise he is one of the renowned and best ivf specialist in India. He has performed many successful pre-implantation genetic screening which helped in healthy pregnancy.
Genetics: An Introduction
Each cell in a healthy person has 23 pairs of chromosomes.
Each pair of these chromosomes is inherited from the mother (purple) and the father (blue).
These chromosomes’ building parts are genes.
Genes are the instructions that inform the body how to create proteins that allow it to develop, grow, and operate. They determine our blood group, height, eye color, and hair color, among other things.
The PGT-A Methodology
Initial Assessment:
The fertility specialist will ask about the couple’s reproductive history and propose fertility testing to see whether IVF is a good fit for them. If it is, PGT-A will be addressed. The pair will have to go through the same exams as they would for an IVF round.
Blood samples from you and your spouse will be taken to create DNA probes that will be used to examine the cells. A genetic counselor will answer all of your treatment questions and go through your case, the PGT-A procedure, and your choices with you.
IVF
PGT-A is used in combination with IVF, and patients must undergo ovarian hyperstimulation, egg harvesting, and IVF to generate the most embryos for further evaluation. ICSI may be necessary in some cases.
Cell Preparation & Embryo Biopsy:
On the 5th or 6th day of culture, a few cells are taken from the embryos at the blastocyst stage of development. PGT cannot be performed on embryos that have not matured during blastocyst culture. PGT-A analysis is performed when the biopsied cells are moved to a tiny tube. Embryologists will examine the findings of the biopsy and distinguish between healthy and defective embryos. The embryos are vitrified/frozen and kept in a freezer until they are ready to be transferred.
Analysis of PGT:
Embryologists study biopsied cells using cutting-edge technology to discover genetic abnormalities or mutant gene sequences. In addition, the sequences of all 22 pairs of chromosomes were screened.
Transfer of Embryos:
With the patients, the embryologist and physician go through the PGT results. The chosen and the cryopreserved embryo is thawed before being helped in hatching. Assisted hatching helps the embryo to break free from the zona pellucida, a protective layer that promotes implantation.
To enhance implantation efficiency, the embryo is delivered to the uterine cavity by ultrasonography. To assist decrease the chances of multiple gestations, the fertility specialist can securely select to transfer only one embryo at a time.
While a successful pregnancy cannot be guaranteed, based on individual conditions connected to having PGT-A, a 60-70 percent success rate can be predicted.
Who is a good candidate for PGT-A?
PGT-A is a suitable choice for couples who have a greater risk of chromosomal abnormalities in their embryos, while PGT is a good alternative for individuals who:
Who have experienced several implant failures
Women who have had several miscarriages
Couples who have had numerous unsuccessful IVF cycles
Women who are nearing the end of their pregnancy (over 35)
Are you worried about having a child that is free of hereditary disorders?
PGT-A has the following advantages:
IVF success rates have improved.
Pregnancy rates per transfer are higher.
Miscarriage risk is reduced.
IVF treatment cycles must be reduced.
Having a healthy child is more likely.
Dr. Hrishikesh Pai employs the most cutting-edge genomic tests and technologies available, ensuring accurate results, early diagnosis, and the transfer of a genetically normal embryo.
IVF using PGT-A improves the chances of a successful IVF cycle for many couples. PGT-A has become a standard element of IVF, allowing patients with serious illnesses to achieve their aspirations of having a healthy child.
Consult our expert fertility specialists if you’d like to learn more about how PGT-A might help you get pregnant faster or if you’d like to know what your choices are.